CEP70 is the official symbol for centrosomal protein 70, a human protein-coding gene. It is also listed under the synonym BITE. The gene is associated with centrosome and microtubule biology.
Centrosomes are major microtubule-organising centres in human cells. They help control cell shape, intracellular transport and the formation of the mitotic spindle during cell division.
Gene and Protein
NCBI Gene lists human CEP70 as Gene ID 80321. Ensembl identifies the gene as ENSG00000114107 on chromosome 3. UniProt lists the reviewed human protein entry as Q8NHQ1, centrosomal protein of 70 kDa.
The encoded protein is reported at protein level in UniProt and the Human Protein Atlas. Like many centrosomal proteins, CEP70 is mainly discussed in relation to cell structure, microtubule organisation and mitosis.
Cellular Role
UniProt describes CEP70 as playing a role in the organisation of both existing and new microtubules in interphase cells. During mitosis, it is required for the organisation and orientation of the mitotic spindle.
Laboratory research has reported that CEP70 localises to the centrosome throughout the cell cycle and interacts with gamma-tubulin. That interaction is relevant because gamma-tubulin is a key centrosomal component involved in microtubule nucleation.
Centrosomes and Microtubules
Microtubules form part of the cell's cytoskeleton. They support cell shape, intracellular movement and chromosome separation during cell division.
The Human Protein Atlas describes the centrosome as the main microtubule-organising centre in human cells. During cell division, centrosome function is important for correct spindle formation and the separation of sister chromatids.
Expression and Data Resources
Public gene databases provide different kinds of CEP70 information:
- NCBI Gene gives identifiers, genomic context and links to sequences and publications.
- UniProt summarises protein function, sequence, subcellular information and evidence.
- The Human Protein Atlas summarises protein evidence, tissue data and subcellular data.
- Ensembl gives genome location, transcript models and cross-references.
These resources are useful because many small gene pages can otherwise overstate what is known from limited experimental work.
Clinical Research
CEP70 is mainly a cell-biology gene in public reference databases. Some research has examined possible links between CEP70 variation and reproductive biology, including male infertility, but the gene is not usually presented as a routine diagnostic topic in general medical sources.
Claims about disease involvement should therefore be tied to specific studies or curated gene-disease databases rather than stated as established clinical fact.
See Also
References
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