Sjögren's Syndrome

From iWiki

Sjögren's syndrome is a chronic autoimmune disorder characterized by dryness of the eyes and mouth. It can also affect other parts of the body, including the salivary glands, joints, skin, and various organs. The condition is named after Dr. Henrik Sjögren, the Swedish ophthalmologist who first described it in 1933.


The primary symptoms of Sjögren's syndrome include:

  • Dry Eyes (Xerophthalmia): Persistent dryness, gritty sensation, redness, and sensitivity to light in the eyes.
  • Dry Mouth (Xerostomia): Reduced saliva production, leading to a dry mouth, difficulty swallowing or speaking, and an increased risk of dental cavities and oral infections.
  • Salivary Gland Swelling: Swelling and tenderness of the salivary glands, particularly the parotid glands in front of the ears.
  • Joint Pain and Swelling: Joint pain, stiffness, and swelling, similar to symptoms of rheumatoid arthritis.
  • Skin Dryness: Dry skin, particularly on the hands and feet.
  • Vaginal Dryness: Dryness and discomfort in the vaginal area.
  • Persistent Fatigue: Profound and persistent fatigue, often accompanied by a general feeling of unwellness.
  • Other Organ Involvement: Sjögren's syndrome can also affect other organs, such as the lungs, kidneys, liver, and nervous system.

Causes and Risk Factors

The exact cause of Sjögren's syndrome remains unknown. It is believed to result from a combination of genetic, hormonal, and environmental factors. Potential risk factors include:

  • Gender: The condition predominantly affects women, with a female-to-male ratio of approximately 9:1.
  • Age: Sjögren's syndrome can occur at any age, but it most commonly develops between the ages of 40 and 60.
  • Other Autoimmune Conditions: Individuals with other autoimmune diseases, such as rheumatoid arthritis or lupus, have a higher risk of developing Sjögren's syndrome.


Diagnosing Sjögren's syndrome involves a comprehensive evaluation of symptoms, medical history, and specific diagnostic tests. These may include:

  • Eye and Mouth Examinations: Evaluation of eye dryness, measurement of tear production, and examination of salivary gland function.
  • Blood Tests: Detection of specific antibodies commonly associated with Sjögren's syndrome, such as anti-SSA (Ro) and anti-SSB (La) antibodies.
  • Imaging Tests: Imaging studies, such as salivary gland scintigraphy or ultrasound, may be used to assess salivary gland function and detect abnormalities.
  • Biopsy: In some cases, a minor salivary gland biopsy may be performed to evaluate glandular inflammation and confirm the diagnosis.


The management of Sjögren's syndrome aims to relieve symptoms, prevent complications, and improve quality of life. Treatment options may include:

  • Artificial Tears and Eye Lubricants: Over-the-counter or prescription eye drops to relieve dryness and improve eye lubrication.
  • Saliva Substitutes and Dental Care: Use of saliva substitutes, frequent sips of water, and good oral hygiene practices to manage dry mouth and prevent dental complications.
  • Immunosuppressive Medications: Medications such as corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and biologics may be prescribed to reduce inflammation and suppress the immune response.
  • Symptom-Specific Treatment: Management of specific symptoms, such as joint pain or vaginal dryness, through medications, physical therapy, or other interventions.
  • Lifestyle Modifications: Avoidance of triggers that worsen symptoms, such as dry environments or certain medications, and adopting strategies to manage fatigue and maintain overall health.


The prognosis for individuals with Sjögren's syndrome varies. While the condition is chronic and may require ongoing management, most people can lead productive lives with appropriate treatment. Regular follow-up care, including monitoring for complications and managing symptoms, is essential to maintain optimal health.

See Also